Imagine if you could reduce your biological age by over 50% through a basic injection. Sounds like something out of a science fiction story, doesn’t it? But now, it’s not just a fantasy. Yuvan Research’s revolutionary study has proven that it is indeed achievable by transferring the epigenetic data from one species to another.
Epigenetics is the study of how environmental factors affect the expression of genes. Epigenetic information is encoded in the DNA by a process called methylation, which adds or removes chemical groups to the DNA. Methylation patterns change over time and reflect the biological age of an organism.
Yuvan Research has developed a therapy, called E5, that uses extracellular nanoparticles sourced from young pig plasma to transfer the epigenetic information from pigs to rats. The nanoparticles are tiny vesicles that carry the DNA and RNA molecules from the pig cells. By injecting these nanoparticles into old rats, the researchers were able to reset their methylation patterns and reverse their biological age by over 50%.
The age reversal was measured by epigenetic clocks, which use mathematical algorithms to calculate the biological age based on the methylation levels. The researchers used two different epigenetic clocks, one for rats and one for humans, and found that both showed consistent results. The therapy reduced the biological age of 24-month-old rats (equivalent to 80-year-old humans) to 11.8-month-old rats (equivalent to 26-year-old humans).
The therapy is not just a cosmetic intervention. It rejuvenates the cells and tissues at the molecular level. It restores the functionality and vitality of the organism. The treated rats showed improved cognitive performance, physical endurance, and immune response. They also had lower levels of inflammation, oxidative stress, and senescence, which are associated with aging and chronic diseases.
The therapy is safe, effective, and scalable. It does not necessitate genetic engineering or stem cells. It can be easily administered through a simple injection. The researchers have already conducted tests on dogs and monkeys, yielding comparable outcomes. They are currently preparing to commence human trials in the near future.
As Akshay Sanghavi, a co-founder of Yuvan Research, who initiated this endeavor to “cure” aging after his mother’s loss to diabetes, affirms, “This study demonstrates the potential to reverse biological aging.” Another aging clock, GlycanAge, has also validated these findings, indicating a reduction of approximately 50% in biological age.
Interestingly, the research has potential beyond humans. Michael Snyder, Chair of the Department of Genetics and Professor of Genetics at Stanford University, who is on the Scientific Advisory Board of Yuvan Research, noted that the results are stunning and have enormous potential for animals as well, including pets. This suggests that our furry friends may also benefit from the age-reversing effects of the E5 therapeutic.
Furthermore, the implications of the research could extend to the fields of conservation biology and animal husbandry, opening up wide-ranging possibilities. The ability to extend the healthy lifespan of other species could revolutionise the way we approach conservation and animal care.
The study was published in the journal Nature Communications on November 1, 2023.
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– Extracellular Nanoparticles Sourced From Another Species Reverses Biological Age of Rats by More Than 50%, Lifestyle Blog, 1 November 2023